SCHEMBL7036233

SCHEMBL7036233

[CH2]C1Cn2cc(C(=O)NCc3ccc(Cl)cc3)c(=O)c3cc(CN4CCOCC4)cc(c32)O1

nearest known ligand 0.65

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
POLA1 P09884 2/20 0.65
KCNH2 Q12809 7/20 0.62
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
F2 P00734 1/20 0.46
ALDH1A1 P00352 1/20 0.43
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7030685 0.91 POLA1 (0.54) POLA1KCNH2MEN1KMT2AALDH1A1
SCHEMBL6697011 0.90 POLA1 (0.65) POLA1KCNH2MEN1KMT2AF2
SCHEMBL6701354 0.90 POLA1 (0.65) POLA1KCNH2MEN1KMT2AF2
SCHEMBL7031095 0.88 POLA1 (0.65) POLA1KCNH2MEN1KMT2AF2
SCHEMBL6698313 0.88 POLA1 (0.63) POLA1KCNH2MEN1KMT2AF2
SCHEMBL6703845 0.88 POLA1 (0.62) POLA1KCNH2MEN1KMT2AF2
SCHEMBL6702905 0.88 POLA1 (0.64) POLA1KCNH2MEN1KMT2AF2
SCHEMBL6702853 0.88 POLA1 (0.62) POLA1KCNH2MEN1KMT2AF2
SCHEMBL6698911 0.87 POLA1 (0.60) POLA1KCNH2MEN1KMT2AF2
SCHEMBL6697437 0.87 POLA1 (0.61) POLA1KCNH2MEN1KMT2AF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1299395-B1 OXAZINOQUINOLONES USEFUL FOR THE TREATMENT OF VIRAL INFECTIONS UPJOHN CO (US) 2004-09-15 EP claimed