Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 16/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036796 | 1.00 | ADRB3 (0.51) | ADRB3ARNPC1HPGDRAB9A | |
| SCHEMBL7040811 | 0.90 | ADRB3 (0.57) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7040810 | 0.90 | ADRB3 (0.57) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7042542 | 0.90 | ADRB3 (0.57) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7041464 | 0.89 | ADRB3 (0.56) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7041459 | 0.89 | ADRB3 (0.56) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7035908 | 0.89 | ADRB3 (0.56) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7044277 | 0.85 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7044256 | 0.85 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7044253 | 0.85 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659737-B1 | Catecholamine surrogates useful as beta 3 agonists | BRISTOL MYERS SQUIBB CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0659737-A2 | Catecholamine surrogates useful as B3 agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-28 | — | — | EP | disclosed |