SCHEMBL7038439

SCHEMBL7038439

COC(=O)c1cc(-c2cccc(NC(C)=O)c2)ccc1NC(=O)c1ccc(Cl)cc1Cl

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.55
MAPT P10636 5/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
PPARA Q07869 4/20 0.54
SMN1; SMN2 Q16637 3/20 0.53
TP53 P04637 3/20 0.50
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
HTT P42858 2/20 0.49
ALDH1A1 P00352 1/20 0.49
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
ATM Q13315 1/20 0.47
LMNA P02545 2/20 0.47
NPSR1 Q6W5P4 1/20 0.47
KDM4E B2RXH2 2/20 0.47
PYGL P06737 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7039302 0.89 PPARG (0.61) PPARGMAPTL3MBTL1PPARASMN1; SMN2
SCHEMBL7038586 0.87 PPARG (0.61) PPARGPPARASMN1; SMN2TP53ALDH1A1
SCHEMBL7040693 0.87 PPARG (0.60) PPARGMAPTPPARATP53MEN1
SCHEMBL7038678 0.84 PPARG (0.76) PPARGMAPTPPARATP53ALDH1A1
SCHEMBL7040486 0.83 PPARG (0.55) PPARGMAPTPPARASMN1; SMN2TP53
SCHEMBL7038571 0.83 PPARG (0.57) PPARGMAPTPPARASMN1; SMN2TP53
SCHEMBL7038602 0.82 PPARG (0.54) PPARGMAPTPPARASMN1; SMN2TP53
SCHEMBL7039954 0.82 PPARG (0.80) PPARGMAPTPPARATP53MEN1
SCHEMBL7041638 0.82 PPARG (0.60) PPARGMAPTPPARASMN1; SMN2TP53
Lithium SCHEMBL7039319 0.82 PPARG (0.53) PPARGMAPTPPARASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030073862-A1 Compounds BIOVITRUM AB (SE) 2003-04-17 US disclosed
WO-2003004458-A1 NEW COMPOUNDS BIOVITRUM AB (SE) 2003-01-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030073862-A1 Compounds PPARG, PPARA, PPARD PPARG 1/4885MAPT 4479/4885L3MBTL1 3026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.