⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30644320 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL4605896 | 0.97 | HCAR2 (0.41) | — | |
| Hydrochloric Acid SCHEMBL3934248 | 0.97 | — | — | |
| Formaldehyde SCHEMBL29107865 | 0.93 | HCAR2 (0.43) | — | |
| SCHEMBL56635 | 0.78 | — | — | |
| SCHEMBL187404 | 0.78 | — | — | |
| Bromide SCHEMBL7898147 | 0.76 | MEN1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL3583511 | 0.76 | — | — | |
| Ammonia Solution, Strong SCHEMBL28242958 | 0.76 | HCAR2 (0.50) | — | |
| SCHEMBL21044202 | 0.72 | TAAR1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 774 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098018-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | CYTOKINETICS INC (US) | 2026-04-09 | — | — | US | claimed |
| US-12479824-B2 | Method for preparing ivosidenib and an intermediate thereof | SERVIER PHARMACEUTICALS LLC (US) | 2025-11-25 | — | — | US | claimed |
| CN-119899194-B | Bicyclic heteroaryl BRAF negative allosteric modulator, and preparation method and application thereof | 浙江省人民医院 | 2025-06-24 | — | — | CN | claimed |
| CN-119899194-A | Bicyclic heteroaryl BRAF negative allosteric modulator, and preparation method and application thereof | 浙江省人民医院 | 2025-04-29 | — | — | CN | claimed |
| CN-119432148-A | Perovskite ink, perovskite film and battery device | 云南大学 | 2025-02-14 | — | — | CN | claimed |
| CN-119082658-A | High-strength and high-toughness microalloy structural steel and preparation method thereof | 河北纵横集团丰南钢铁有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-114555584-B | Ai Funi cloth (IVOSIDENIB) and process for producing intermediate thereof | 法国施维雅药厂 | 2024-07-05 | — | — | CN | claimed |
| EP-4010331-B1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | SERVIER LAB (FR) | 2023-10-04 | — | — | EP | claimed |
| US-20230025411-A1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | SERVIER PHARMACEUTICALS LLC | 2023-01-26 | — | — | US | claimed |
| EP-4010331-A1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | Les Laboratoires Servier (FR) | 2022-06-15 | — | — | EP | claimed |
| WO-2021079380-A1 | IMPROVED PROCESS FOR THE PREPARATION OF (2S)-N-{(1S)-1-(2-CHLOROPHENYL)-2-[(3,3-DIFLUOROCYCLOBUTYL)-AMINO]-2-OXOETHYL}-1-(4-CYANOPYRIDIN-2-YL)-N-(5-FLUOROPYRIDIN-3-YL)-5-OXOPYRROLIDINE-2-CARBOXAMIDE | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2021-04-29 | — | — | WO | claimed |
| CN-112367995-A | Evonib forms and pharmaceutical compositions | 安吉奥斯医药品有限公司 | 2021-02-12 | — | — | CN | claimed |
| WO-2021026436-A1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | AGIOS PHARMACEUTICALS, INC. (US) | 2021-02-11 | — | — | WO | claimed |
| CN-111349081-B | Chiral synthesis method of Ivosidenib and intermediate thereof | 宁波大学科学技术学院 | 2021-01-15 | — | — | CN | claimed |
| CN-109678793-B | Preparation method of 5-fluoro-3-aminopyridine | 上海卡洛化学有限公司 | 2020-08-04 | — | — | CN | claimed |
| CN-111349081-A | Chiral synthesis method of Ivosidenib and intermediate thereof | 宁波大学科学技术学院 | 2020-06-30 | — | — | CN | claimed |
| US-20150274661-A1 | INDOL-AMIDE COMPOUNDS AS BETA-AMYLOID INHBITORS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-01 | — | — | US | claimed |
| EP-2909190-A1 | INDOL-AMIDE COMPOUNDS AS BETA-AMYLOID INHBITORS | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | claimed |
| WO-2014060386-A1 | INDOL-AMIDE COMPOUNDS AS BETA-AMYLOID INHBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | claimed |
| EP-2722329-A1 | Indol-amide compounds as beta-amyloid inhbitors | F. Hoffmann-La Roche AG (CH) | 2014-04-23 | — | — | EP | claimed |