⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL686322 | 0.69 | — | — | |
| SCHEMBL9635466 | 0.69 | — | — | |
| Bromide SCHEMBL11611722 | 0.67 | — | — | |
| Bromide SCHEMBL8756213 | 0.67 | — | — | |
| SCHEMBL1833885 | 0.67 | — | — | |
| SCHEMBL6728345 | 0.65 | — | — | |
| SCHEMBL10250397 | 0.63 | — | — | |
| SCHEMBL35598 | 0.62 | — | — | |
| SCHEMBL6911543 | 0.57 | — | — | |
| SCHEMBL10035465 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030100605-A1 | Methods of treating cancer with angiogenesis inhibitors | GRUPP STEPHAN A (US) | 2003-05-29 | — | — | US | disclosed |
| US-6017954-A | ANGIOGENESIS INHIBITORS FOR TREATING AND PREVENTING ANGIOGENESIS-DEPENDENT TUMORS, ESPECIALLY KAPOSI'S SARCOMA, BREAST CANCER, COLON CANCER | CHILDREN'S MEDICAL CENTER CORP. (US) | 2000-01-25 | — | — | US | disclosed |
| US-5698586-A | ADMINISTERING AN O-SUBSTITUTED FUMAGILLOL | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0359036-B1 | Fumagillol derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-03-26 | — | — | EP | disclosed |
| EP-0682020-A1 | Fumagillol derivatives useful as angiogenesis inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-11-15 | — | — | EP | disclosed |
| EP-0357061-B1 | Angiogenesis inhibitory agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-06-08 | — | — | EP | disclosed |
| US-5290807-A | Antiinflammatory agents | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1994-03-01 | — | — | US | disclosed |
| US-5180738-A | Angiogenesis Inhibitors | TAKEDA CHEMICAL INDUSTRIES (JP) | 1993-01-19 | — | — | US | disclosed |
| US-5166172-A | Angiogenesis inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5164410-A | Fumagillol derivatives and pharmaceutical compositions thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-11-17 | — | — | US | disclosed |
| EP-0359036-A1 | Fumagillol derivatives | Takeda Chemical Industries, Ltd. (JP) | 1990-03-21 | — | — | EP | disclosed |
| EP-0357061-A1 | Angiogenesis inhibitory agent | Takeda Chemical Industries, Ltd. (JP) | 1990-03-07 | — | — | EP | disclosed |