Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036398 | 0.87 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11CHRNA7 | |
| SCHEMBL7035922 | 0.86 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7036533 | 0.85 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7037904 | 0.83 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7038383 | 0.82 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7032178 | 0.79 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7593836 | 0.79 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL1901734 | 0.78 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7037212 | 0.78 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL1899616 | 0.77 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| EP-1289958-A2 | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) | Leo Pharma A/S (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |
| WO-2001090074-A2 | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | LEO PHARMA A/S (DK) | 2001-11-29 | — | — | WO | disclosed |