Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043301 | 0.91 | GRIN1 (0.41) | POLBMEN1CYP1A2TSHRAPEX1 | |
| SCHEMBL7044504 | 0.76 | GRIN1 (0.39) | POLBMEN1CYP1A2TSHRAPEX1 | |
| SCHEMBL6732401 | 0.74 | CYP19A1 (0.32) | POLBMEN1CYP1A2TSHRAPEX1 | |
| SCHEMBL7043309 | 0.70 | GRIN1 (0.42) | POLBMEN1CYP1A2TSHRAPEX1 | |
| SCHEMBL30631965 | 0.69 | TSHR (0.51) | POLBMEN1CYP1A2TSHRAPEX1 | |
| SCHEMBL22655992 | 0.69 | TSHR (0.51) | POLBMEN1CYP1A2TSHRAPEX1 | |
| SCHEMBL6730275 | 0.67 | CYP1A2 (0.41) | POLBMEN1CYP1A2TSHRAPEX1 | |
| SCHEMBL31655488 | 0.66 | GRIN1 (0.38) | CYP1A2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL22875350 | 0.64 | KDM1A (0.44) | POLB | |
| SCHEMBL22147812 | 0.62 | GRIN1 (0.49) | POLBMEN1CYP1A2TSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007940-A1 | LACTAM AND THIOLACTAM DERIVATIVES AS ANESTHETIC AND CONSCIOUS SEDATION AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2003-01-30 | — | — | WO | disclosed |