Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 10/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368048 | 0.85 | FOLH1 (0.69) | FOLH1ALDH1A1MRGPRX4FFAR4 | |
| SCHEMBL4379735 | 0.85 | FOLH1 (0.69) | FOLH1ALDH1A1MRGPRX4FFAR4 | |
| SCHEMBL4379587 | 0.84 | FOLH1 (0.81) | FOLH1PPARAFFAR4HTTFFAR1 | |
| SCHEMBL4374230 | 0.84 | FOLH1 (1.00) | FOLH1ALDH1A1PPARAMRGPRX4TP53 | |
| SCHEMBL4379752 | 0.83 | FOLH1 (1.00) | FOLH1 | |
| SCHEMBL4380757 | 0.83 | FOLH1 (0.74) | FOLH1FFAR4FFAR1 | |
| SCHEMBL4373083 | 0.83 | FOLH1 (0.74) | FOLH1FFAR4TP53HTTFFAR1 | |
| SCHEMBL4368704 | 0.82 | FOLH1 (0.77) | FOLH1ALDH1A1MRGPRX4FFAR4FFAR1 | |
| SCHEMBL4371610 | 0.82 | FOLH1 (0.68) | FOLH1ALDH1A1MRGPRX4FFAR4FFAR1 | |
| SCHEMBL4367224 | 0.82 | FOLH1 (0.68) | FOLH1ALDH1A1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292601-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2001092274-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2001-12-06 | — | — | WO | claimed |