Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.65 |
| ▸ | PPARD | Q03181 | 10/20 | 0.65 |
| ▸ | PPARA | Q07869 | 10/20 | 0.65 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439853 | 0.92 | PPARG (0.59) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8442985 | 0.90 | PPARG (0.58) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8443074 | 0.90 | PPARG (0.57) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8442424 | 0.89 | PPARG (0.59) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6939098 | 0.89 | PPARG (0.58) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6936613 | 0.88 | PPARG (0.70) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8440918 | 0.88 | PPARG (0.59) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8665443 | 0.88 | PPARG (0.57) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6935505 | 0.87 | PPARG (0.73) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6937386 | 0.87 | PPARG (0.84) | PPARGPPARDPPARANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6090836-A | DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0882029-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028137-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |