Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | GLI2 | P10070 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
| ▸ | CASP7 | P55210 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7038621 | 0.93 | ESR1 (0.79) | ESR1ESR2PTGS2MAPK14MAPK13 | |
| SCHEMBL7042915 | 0.93 | ESR1 (0.79) | ESR1ESR2PTGS2MAPK14MAPK13 | |
| SCHEMBL5193971 | 0.89 | ESR1 (0.73) | ESR1ESR2PTGS2KDM4EALDH1A1 | |
| SCHEMBL7038838 | 0.86 | ESR1 (0.63) | ESR1ESR2PTGS2CYP3A4BLM | |
| SCHEMBL7037980 | 0.83 | ESR1 (1.00) | ESR1ESR2PTGS2MAPK14 | |
| SCHEMBL7039129 | 0.81 | ESR1 (0.61) | ESR1ESR2PTGS2MAPK14MAPK13 | |
| SCHEMBL7040440 | 0.80 | ESR1 (1.00) | ESR1ESR2PTGS2MAPK14KDM4E | |
| SCHEMBL31060913 | 0.80 | ESR1 (1.00) | ESR1ESR2PTGS2MAPK14KDM4E | |
| SCHEMBL28383145 | 0.80 | NR1I2 (0.58) | ESR1ESR2PDPK1HSP90AB1KDM4E | |
| SCHEMBL7041571 | 0.80 | ESR1 (1.00) | ESR1ESR2PTGS2MAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220377-A1 | Indole compounds and their use as estrogen agonists/antagonists | CHESWORTH RICHARD (US) | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220377-A1 | Indole compounds and their use as estrogen agonists/antagonists | ESR1, GPER1, ESR2 | ESR1 1/4885ESR2 3/4885PTGS2 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.