Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.59 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.59 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 13/20 | 0.52 |
| ▸ | TOP2A | P11388 | 2/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olamufloxacin SCHEMBL1851976 | 1.00 | KCNH2 (0.59) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| Olamufloxacin SCHEMBL31162720 | 1.00 | KCNH2 (0.59) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| Olamufloxacin SCHEMBL29711354 | 0.96 | KCNH2 (0.55) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9079484 | 0.94 | CACNA1F (0.67) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9136561 | 0.93 | MEN1 (0.50) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9023781 | 0.91 | KCNH2 (0.56) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9023386 | 0.90 | KCNH2 (0.60) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9023755 | 0.90 | KCNH2 (0.60) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9080555 | 0.89 | POLB (0.57) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9023715 | 0.89 | KCNH2 (0.56) | KCNH2POLBCACNA1FMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641793-B1 | 5-Amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative | HOKURIKU PHARMACEUTICAL (JP) | 1996-10-23 | — | — | EP | claimed |
| EP-0641793-A1 | 5-Amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-08 | — | — | EP | claimed |
| US-6825353-B2 | AN AMINE SUBSTITUENT AT THE 7-POSITION OF THE QUINOLONE-CARBOXYLIC ACID DERIVATIVE IS PRODUCED; BACTERICIDES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20030060631-A1 | Process for producing quinolonecarboxlic acids and intermediates thereof | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-03-27 | — | — | US | disclosed |
| CN-1048242-C | 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative | NORTHERN CONTINENTAL CO LTD (JP) | 2000-01-12 | — | — | CN | disclosed |
| EP-0641793-B1 | 5-Amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative | HOKURIKU PHARMACEUTICAL (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5547962-A | QUINOLONE ANTIBIOTICS | HORURIKU SEIYAKU CO., LTD. (JP) | 1996-08-20 | — | — | US | disclosed |
| CN-1117491-A | 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative | NORTHERN CONTINENTAL CO LTD (JP) | 1996-02-28 | — | — | CN | disclosed |
| EP-0641793-A1 | 5-Amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060631-A1 | Process for producing quinolonecarboxlic acids and intermediates thereof | NQO2, QPCT, QARS1 | KCNH2 3199/4885POLB 1231/4885CACNA1F 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.