Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 8/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | TYK2 | P29597 | 2/20 | 0.30 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700405 | 0.88 | PARP1 (0.48) | TAAR1PARP1PARP2PARP3 | |
| SCHEMBL7041163 | 0.85 | TAAR1 (0.41) | TAAR1PARP1PARP2PARP3ALDH1A1 | |
| SCHEMBL7041778 | 0.84 | JAK2 (0.42) | TAAR1PARP1PARP2PARP3JAK2 | |
| SCHEMBL7043781 | 0.84 | TAAR1 (0.41) | TAAR1PARP1PARP2PARP3JAK2 | |
| SCHEMBL7043517 | 0.83 | MEN1 (0.41) | TAAR1PARP1PARP2PARP3LMNA | |
| SCHEMBL7041803 | 0.83 | TAAR1 (0.41) | TAAR1PARP1PARP2PARP3TDP1 | |
| SCHEMBL7040702 | 0.82 | KMT2A (0.42) | TAAR1PARP1PARP2PARP3LMNA | |
| SCHEMBL7046415 | 0.82 | TAAR1 (0.40) | TAAR1PARP1PARP2PARP3ALDH1A1 | |
| SCHEMBL7041448 | 0.81 | TAAR1 (0.36) | TAAR1PARP1LMNA | |
| SCHEMBL7041738 | 0.81 | TAAR1 (0.54) | TAAR1PARP1PARP2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |