Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045454 | 1.00 | KMT2A (0.58) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL6458735 | 0.91 | MAPT (0.46) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL6458744 | 0.91 | MAPT (0.46) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL6876902 | 0.90 | TDP1 (0.59) | KMT2AMEN1ALDH1A1POLBTDP1 | |
| SCHEMBL6876908 | 0.90 | TDP1 (0.59) | KMT2AMEN1ALDH1A1POLBTDP1 | |
| SCHEMBL6467792 | 0.90 | KMT2A (0.43) | KMT2AMEN1ALDH1A1POLBTP53 | |
| SCHEMBL6872085 | 0.90 | KMT2A (0.43) | KMT2AMEN1ALDH1A1POLBTP53 | |
| SCHEMBL6874359 | 0.90 | MCHR1 (0.48) | KMT2AMEN1POLBMAPTADRA1A | |
| SCHEMBL6868128 | 0.90 | MCHR1 (0.46) | KMT2AMEN1ALDH1A1MAPTADRA1A | |
| SCHEMBL6874353 | 0.90 | MCHR1 (0.48) | KMT2AMEN1POLBMAPTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |