Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.52 |
| ▸ | IGF1R | P08069 | 16/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 15/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | PAK4 | O96013 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826510 | 0.86 | EGFR (0.57) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL4820543 | 0.85 | EGFR (0.69) | EGFRIGF1RERBB4BTKLCK | |
| SCHEMBL4818658 | 0.84 | EGFR (0.62) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL4824621 | 0.81 | EGFR (0.61) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL4826144 | 0.81 | EGFR (0.58) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL4826042 | 0.80 | EGFR (0.57) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL6430643 | 0.79 | EGFR (0.70) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL4820389 | 0.79 | KDR (0.61) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL6431893 | 0.78 | EGFR (0.67) | EGFRIGF1RERBB4AURKBBTK | |
| SCHEMBL3891960 | 0.78 | EGFR (0.72) | EGFRIGF1RERBB4AURKBBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004100868-A2 | METHOD OF TREATING TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 2004-11-25 | — | — | WO | disclosed |