Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 6/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CTSG | P08311 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PPM1B | O75688 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2387693 | 0.85 | TSHR (0.55) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL5317413 | 0.85 | TSHR (0.55) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL2387697 | 0.85 | TSHR (0.55) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL11545787 | 0.85 | TSHR (0.55) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL2387688 | 0.85 | TSHR (0.55) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL7047733 | 0.85 | CAPN1 (0.48) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL5556039 | 0.83 | TSHR (0.53) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL15171333 | 0.80 | CAPN1 (0.58) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL14067709 | 0.80 | CAPN1 (0.51) | CAPN1CTSLCTSBLMNACTSG | |
| SCHEMBL11171419 | 0.80 | CAPN1 (0.51) | CAPN1CTSLCTSBLMNACTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1029869-B1 | Endothelin converting enzyme inhibitors | WELLCOME FOUND (GB) | 2003-04-23 | — | — | EP | disclosed |
| US-6235717-B1 | Pharmaceutical compounds | GLAXO WELLCOME INC. | 2001-05-22 | — | — | US | disclosed |
| EP-1029869-A1 | Endothelin converting enzyme inhibitors | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-08-23 | — | — | EP | disclosed |
| EP-0677059-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994015956-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-21 | — | — | WO | disclosed |