Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.56 |
| ▸ | HTR2B | P41595 | 6/20 | 0.56 |
| ▸ | HRH1 | P35367 | 5/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047759 | 1.00 | MCHR1 (0.56) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6878002 | 0.92 | MCHR1 (0.54) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868889 | 0.92 | MCHR1 (0.58) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868725 | 0.92 | MCHR1 (0.58) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868895 | 0.92 | MCHR1 (0.58) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875374 | 0.92 | MCHR1 (0.54) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6878008 | 0.92 | MCHR1 (0.54) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868729 | 0.92 | MCHR1 (0.58) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875373 | 0.92 | MCHR1 (0.54) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868089 | 0.90 | MCHR1 (0.54) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |