Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.60 |
| ▸ | EGFR | P00533 | 7/20 | 0.60 |
| ▸ | LCK | P06239 | 4/20 | 0.60 |
| ▸ | ITK | Q08881 | 4/20 | 0.60 |
| ▸ | JAK3 | P52333 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | TEC | P42680 | 3/20 | 0.53 |
| ▸ | BMX | P51813 | 3/20 | 0.53 |
| ▸ | TXK | P42681 | 2/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.53 |
| ▸ | LATS1 | O95835 | 1/20 | 0.53 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136335 | 0.97 | BTK (0.60) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL7140710 | 0.96 | BTK (0.61) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL6432745 | 0.96 | BTK (0.64) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL6432266 | 0.95 | BTK (0.62) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL7133348 | 0.89 | BTK (0.64) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL6434970 | 0.89 | BTK (0.66) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL6438149 | 0.85 | BTK (0.70) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL6432923 | 0.84 | BTK (0.65) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL6431323 | 0.84 | BTK (0.67) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL5803146 | 0.84 | BTK (0.59) | BTKEGFRLCKITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004100868-A2 | METHOD OF TREATING TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 2004-11-25 | — | — | WO | disclosed |