Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 9/20 | 0.67 |
| ▸ | GALR3 | O60755 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048273 | 1.00 | CES1 (0.67) | CES1GALR3TGM2HTR2AHTR2C | |
| SCHEMBL6322718 | 0.90 | CES1 (0.61) | CES1GALR3TGM2HTR2AHTR2C | |
| SCHEMBL6316168 | 0.90 | CES1 (0.61) | CES1GALR3TGM2HTR2AHTR2C | |
| SCHEMBL7054756 | 0.81 | CES1 (0.46) | CES1GALR3TGM2 | |
| SCHEMBL7054760 | 0.81 | CES1 (0.46) | CES1GALR3TGM2 | |
| SCHEMBL734955 | 0.81 | CES1 (1.00) | CES1TGM2PDE7A | |
| SCHEMBL7050698 | 0.81 | CES1 (0.42) | CES1GALR3TGM2CA1CA2 | |
| SCHEMBL7050694 | 0.81 | CES1 (0.42) | CES1GALR3TGM2CA1CA2 | |
| SCHEMBL5752424 | 0.77 | CES1 (0.61) | CES1GALR3TGM2HTR2AHTR2C | |
| SCHEMBL8872679 | 0.76 | CES1 (0.41) | CES1GALR3TGM2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |