Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.67 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5850718 | 0.85 | MEN1 (0.65) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL5851416 | 0.84 | MEN1 (0.64) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL7048623 | 0.83 | HTT (0.67) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL5849263 | 0.83 | MEN1 (0.74) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL5849244 | 0.83 | MEN1 (0.60) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL5851284 | 0.82 | MEN1 (0.73) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL5850784 | 0.82 | MEN1 (0.62) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL7060963 | 0.81 | MEN1 (0.78) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL12789922 | 0.81 | P2RY12 (1.00) | MEN1P2RY12HTTTSHRSMN1; SMN2 | |
| SCHEMBL5849178 | 0.79 | MEN1 (0.68) | MEN1P2RY12HTTTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |