Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | MTOR | P42345 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31006694 | 0.90 | SLC6A4 (0.74) | SLC6A4SLC6A2MEN1KMT2ALMNA | |
| SCHEMBL9398389 | 0.90 | SLC6A4 (0.74) | SLC6A4SLC6A2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL29839440 | 0.89 | SLC6A4 (0.75) | SLC6A4SLC6A2MEN1KMT2ALMNA | |
| SCHEMBL4740237 | 0.85 | SLC6A4 (0.78) | SLC6A4SLC6A2MEN1KMT2ALMNA | |
| SCHEMBL7049978 | 0.84 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL9195891 | 0.83 | SLC6A4 (0.60) | SLC6A4CYP2D6CYP2C19CYP2C9HRH3 | |
| Oxalic Acid SCHEMBL4739531 | 0.81 | SLC6A4 (0.72) | SLC6A4SLC6A2MEN1KMT2ALMNA | |
| SCHEMBL2615211 | 0.80 | SLC6A4 (0.85) | SLC6A4SLC6A2MEN1KMT2ALMNA | |
| SCHEMBL2615212 | 0.80 | SLC6A4 (0.85) | SLC6A4SLC6A2MEN1KMT2ALMNA | |
| SCHEMBL14415684 | 0.79 | SLC6A4 (0.87) | SLC6A4SLC6A2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831799-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS | NPS PHARMA INC (US) | 2003-05-02 | — | — | EP | claimed |
| EP-0399504-B1 | Aryloxyphenylpropylamines their preparation and use | NOVO NORDISK AS (DK) | 1995-05-03 | — | — | EP | disclosed |
| US-5310756-A | Aryloxyphenylpropylamines and their calcium overload blocking compositions and methods of use | NOVO NORDISK A/S (DK) | 1994-05-10 | — | — | US | disclosed |
| US-5145870-A | Treating calcium overload in brain cells, anoxia, migraine, ischemia, epilepsy, neurodegenerative diseases | NOVO NORDISK A/S (DK) | 1992-09-08 | — | — | US | disclosed |
| EP-0399504-A2 | Aryloxyphenylpropylamines their preparation and use | NOVO NORDISK A/S (DK) | 1990-11-28 | — | — | EP | disclosed |