Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046248 | 0.83 | GAA (0.57) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL7050416 | 0.81 | GAA (0.55) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL7484968 | 0.81 | GAA (0.55) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL7041161 | 0.76 | GAA (0.52) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL5253476 | 0.71 | GAA (0.63) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL10141247 | 0.71 | GAA (0.63) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL5253472 | 0.71 | GAA (0.63) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL13901608 | 0.71 | GAA (0.63) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL11753054 | 0.71 | GAA (0.63) | GAALMNAALDH1A1NPSR1HPGD | |
| SCHEMBL13664158 | 0.70 | GAA (0.62) | GAALMNAALDH1A1NPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |