SCHEMBL7051316

SCHEMBL7051316

CCc1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)nc(C)nc2s1

nearest known ligand 0.64

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.64
P2RY12 Q9H244 13/20 0.49
CNR2 P34972 1/20 0.48
MEN1 O00255 3/20 0.47
ACACA Q13085 1/20 0.45
GPR55 Q9Y2T6 1/20 0.44
ALDH1A1 P00352 1/20 0.44
KMT2A Q03164 1/20 0.44
GBA1 P04062 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5851438 0.90 P2RY12 (0.49) HTR6P2RY12MEN1ALDH1A1KMT2A
SCHEMBL5849362 0.90 P2RY12 (0.49) HTR6P2RY12MEN1ALDH1A1KMT2A
SCHEMBL4914250 0.89 P2RY12 (0.49) HTR6P2RY12MEN1ALDH1A1KMT2A
SCHEMBL4723775 0.89 P2RY12 (0.49) HTR6P2RY12MEN1ALDH1A1KMT2A
SCHEMBL5851554 0.88 P2RY12 (0.48) HTR6P2RY12MEN1ALDH1A1KMT2A
SCHEMBL5851018 0.88 P2RY12 (0.48) HTR6P2RY12MEN1GBA1
SCHEMBL5850446 0.87 MAPT (0.50) HTR6P2RY12MEN1ALDH1A1KMT2A
SCHEMBL5849520 0.87 P2RY12 (0.49) HTR6P2RY12MEN1ALDH1A1KMT2A
SCHEMBL5850593 0.87 TLR9 (0.57) HTR6P2RY12MEN1GBA1
SCHEMBL5849517 0.87 P2RY12 (0.47) HTR6P2RY12MEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003022214-A2 PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS MILLENNIUM PHARMACEUTICALS, INC. (US) 2003-03-20 WO disclosed