⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26702 | 1.00 | — | — | |
| SCHEMBL565222 | 0.94 | CYP1A2 (0.47) | — | |
| SCHEMBL151183 | 0.94 | CYP1A2 (0.47) | — | |
| SCHEMBL8629808 | 0.94 | — | — | |
| SCHEMBL7571225 | 0.94 | CYP1A2 (0.47) | — | |
| SCHEMBL577198 | 0.94 | CYP1A2 (0.47) | — | |
| Hydrochloric Acid SCHEMBL1775781 | 0.94 | — | — | |
| SCHEMBL1069 | 0.94 | — | — | |
| SCHEMBL23495473 | 0.88 | CYP1A2 (0.44) | — | |
| SCHEMBL17669716 | 0.88 | CYP1A2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0864568-B1 | Agents for treatment of cardiac diseases | KUREHA CHEMICAL IND CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-6242445-B1 | CURATIVE EFFECTS FOR CARDIAC AND NEPHRIC DISEASES, ALTHOUGH HAVING LITTLE ACTION ON BLOOD-PRESSURE. | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| US-6211175-B1 | P-AMINOMETHYLBENZOIC ACID DERIVATIVES; CARDIOVASCULAR DISORDERS; NONHYPOTENSIVE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-1069113-A1 | BENZIMIDAZOLE DERIVATIVE | Kureha Chemical Industry Co., Ltd. (JP) | 2001-01-17 | — | — | EP | disclosed |
| EP-0807628-B1 | Aromatic compound and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 2000-12-20 | — | — | EP | disclosed |
| US-5932575-A | Cardiac diseases improving agents | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5863913-A | ALLEVIATION OF RENAL DYSFUNCTION WITHOUT AFFECTING BLOOD PRESSURE AT A LOW BLOOD CONCENTRATION. | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0864568-A1 | Agents for treatment of cardiac diseases | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| EP-0807628-A1 | Aromatic compound and pharmaceutical composition | Kureha Chemical Industry Co., Ltd. (JP) | 1997-11-19 | — | — | EP | disclosed |