Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6454178 | 0.81 | CYP19A1 (0.46) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 | |
| SCHEMBL6453815 | 0.79 | SMN1; SMN2 (0.50) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 | |
| SCHEMBL6457728 | 0.79 | SMN1; SMN2 (0.47) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 | |
| SCHEMBL6454031 | 0.76 | NPC1 (0.51) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL24462453 | 0.74 | KDM4E (0.66) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 | |
| SCHEMBL27552674 | 0.72 | NPC1 (0.73) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 | |
| SCHEMBL6450069 | 0.72 | NPC1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6450674 | 0.72 | SMN1; SMN2 (0.48) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 | |
| SCHEMBL6450816 | 0.71 | SMN1; SMN2 (0.40) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 | |
| SCHEMBL31119403 | 0.71 | S1PR1 (0.47) | NPC1RAB9AMAPTS1PR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004110351-A2 | HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS | ANADYS PHARMACEUTICALS, INC. (US) | 2004-12-23 | — | — | WO | disclosed |