Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.57 |
| ▸ | TYR | P14679 | 1/20 | 0.57 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | BACE1 | P56817 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22584007 | 0.84 | MAPT (0.54) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL14375127 | 0.84 | APP (0.54) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL6450818 | 0.84 | CYP1A1 (0.54) | CYP1A1CYP1A2CYP1B1MAPTMEN1 | |
| SCHEMBL30194379 | 0.83 | TRIM24 (0.62) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL27959042 | 0.83 | TRIM24 (0.62) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL766043 | 0.83 | TRIM24 (0.62) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL766042 | 0.83 | TRIM24 (0.62) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL26046386 | 0.83 | TRIM24 (0.62) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL31155862 | 0.81 | MAPT (0.62) | TRIM24TYRTRIM33CYP1A1CYP1A2 | |
| SCHEMBL7375952 | 0.81 | MAOB (0.41) | MAPTBACE1APPMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589980-B2 | A compound which is 2,6-dihydroxy-8-methoxy-10,11-dioxa-benzo(b)fluoren-5-one or a pharmaceutically acceptable salt for treating or inhibiting osteoporosis or inhibiting bone demineralization in a mammal in need thereof | WYETH | 2003-07-08 | — | — | US | disclosed |
| US-20030087955-A1 | Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents | WYETH | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087955-A1 | Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents | ESR1, GPER1, ESR2 | TRIM24 2717/4885TYR 1924/4885TRIM33 3998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.