SCHEMBL7053409

SCHEMBL7053409

COc1cc(Oc2cccc(C(F)(F)F)c2)nc(C(N)=O)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.62
L3MBTL1 Q9Y468 3/20 0.49
GAA P10253 2/20 0.49
MAPK1 P28482 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
NTRK1 P04629 1/20 0.46
KDM4E B2RXH2 2/20 0.45
ICAM1 P05362 1/20 0.44
SELE P16581 1/20 0.44
CHEK2 O96017 1/20 0.44
P2RY1 P47900 1/20 0.44
POLB P06746 2/20 0.44
ALDH1A1 P00352 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
F10 P00742 1/20 0.43
MAPK8 P45983 1/20 0.43
MAPK10 P53779 1/20 0.43
RAB9A P51151 1/20 0.43
PLA2G10 O15496 1/20 0.42
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7049881 0.89 MAPT (0.63) MAPTL3MBTL1GAAMAPK1TDP1
SCHEMBL8070245 0.87 MAPT (0.61) MAPTL3MBTL1GAAMAPK1TDP1
SCHEMBL7053451 0.87 MAPT (0.61) MAPTL3MBTL1GAAMAPK1TDP1
SCHEMBL7053854 0.86 MAPT (0.63) MAPTL3MBTL1GAAMAPK1TDP1
SCHEMBL3844011 0.85 MAPT (0.58) MAPTL3MBTL1GAAMAPK1NTRK1
SCHEMBL8773209 0.85 MAPT (0.58) MAPTL3MBTL1GAAMAPK1TDP1
SCHEMBL7051091 0.84 MAPT (0.60) MAPTL3MBTL1GAAMAPK1TDP1
SCHEMBL8569584 0.84 MAPT (0.73) MAPTL3MBTL1GAANTRK1KDM4E
SCHEMBL7053830 0.83 MAPT (0.56) MAPTL3MBTL1GAAMAPK1TDP1
SCHEMBL7050084 0.83 MAPT (0.62) MAPTL3MBTL1GAAMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882715-B1 NOVEL N-(UNSUBSTITUTED OR SUBSTITUTED)-4-SUBSTITUTED-6-(UNSUBSTITUTED OR SUBSTITUTED)PHENOXY-2-PYRIDINECARBOXAMIDES OR THIOCARBOXAMIDES, PROCESSES FOR PRODUCING THE SAME, AND HERBICIDES KUREHA CHEMICAL IND CO LTD (JP) 2003-04-23 EP disclosed
US-6339045-B1 CAN BE USED IN A SMALL AMOUNT, SHOWING A GOOD SELECTIVITY BETWEEN CROP AND WEED, AND CAUSING NO PHYTOTOXICITY KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2002-01-15 US disclosed
EP-0882715-A1 NOVEL N-(UNSUBSTITUTED OR SUBSTITUTED)-4-SUBSTITUTED-6-(UNSUBSTITUTED OR SUBSTITUTED)PHENOXY-2-PYRIDINECARBOXAMIDES OR THIOCARBOXAMIDES, PROCESSES FOR PRODUCING THE SAME, AND HERBICIDES KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1998-12-09 EP disclosed