Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 4/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.33 |
| ▸ | RELA | Q04206 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | STK10 | O94804 | 1/20 | 0.30 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.30 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.30 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.30 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053708 | 1.00 | CES1 (0.44) | CES1GALR3JUNNFKB1NFKB2 | |
| SCHEMBL8871331 | 0.90 | CES1 (0.45) | CES1GALR3JUNNFKB1NFKB2 | |
| SCHEMBL8871333 | 0.90 | CES1 (0.45) | CES1GALR3JUNNFKB1NFKB2 | |
| SCHEMBL7054973 | 0.84 | GALR3 (0.36) | GALR3JUNNFKB1NFKB2RELA | |
| SCHEMBL7054970 | 0.84 | GALR3 (0.36) | GALR3JUNNFKB1NFKB2RELA | |
| SCHEMBL7052798 | 0.83 | GALR3 (0.35) | GALR3KDRACE2 | |
| SCHEMBL7052801 | 0.83 | GALR3 (0.35) | GALR3KDRACE2 | |
| SCHEMBL7052297 | 0.82 | CES1 (0.66) | CES1DNMT1 | |
| SCHEMBL8874088 | 0.82 | CES1 (0.66) | CES1DNMT1 | |
| SCHEMBL7052301 | 0.82 | CES1 (0.66) | CES1DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |