Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14126826 | 0.89 | KDM4E (0.71) | KDM4EL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL7056967 | 0.87 | ADRB3 (0.50) | KDM4EADRB2 | |
| SCHEMBL31270102 | 0.84 | KDM4E (0.66) | KDM4EL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL31270012 | 0.83 | KDM4E (0.64) | KDM4EL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL31269950 | 0.83 | KDM4E (0.64) | KDM4EL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL31270098 | 0.83 | KDM4E (0.64) | KDM4EL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL7051948 | 0.82 | KDM4E (0.60) | KDM4EL3MBTL1SLC18A3SIGMAR1AOC3 | |
| SCHEMBL10877567 | 0.82 | KDM4E (0.88) | KDM4EL3MBTL1 | |
| SCHEMBL10877574 | 0.82 | KDM4E (0.88) | KDM4EL3MBTL1 | |
| SCHEMBL31269959 | 0.78 | KDM4E (0.71) | KDM4EL3MBTL1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940387-B1 | PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6069176-A | PHENYLETHANOLAMINE COMPOUNDS WITH A BETA-3 ADRENERGIC RECEPTOR STIMULATING EFFECT, USE AS A THERAPY FOR URINARY INCONTINENCE | MITSUBISHI-TOKYO PHARMACEUTICALS, INC. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0940387-A1 | PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME | TOKYO TANABE COMPANY LIMITED (JP) | 1999-09-08 | — | — | EP | disclosed |