Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CCR1 | P32246 | 2/20 | 0.54 |
| ▸ | CCR5 | P51681 | 2/20 | 0.54 |
| ▸ | CCR8 | P51685 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29577473 | 0.98 | TP53 (0.59) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL39128 | 0.98 | TP53 (0.59) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL12339129 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL17709417 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL17709414 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL1815589 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E | |
| Hydrochloric Acid SCHEMBL7060038 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL17709412 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL17709413 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E | |
| SCHEMBL346638 | 0.96 | TP53 (0.57) | TP53MEN1KMT2APKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979820-B1 | 2-Phenylpyridine derivatives and production method thereof | SUMIKA FINE CHEMICALS CO LTD (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6268503-B1 | REACTING 2-(4-BROMOMETHYLPHENYL)PYRIDINE SALT OR 2-(4-DIBROMOMETHYLPHENYL)PYRIDINE WITH HEXAMETHYLENETETRAMINE AND WATER TO PROVIDE 4-(PYRIDIN-2-YL)BENZALDEHYDE | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2001-07-31 | — | — | US | disclosed |
| US-6242608-B1 | REACTING 4-(PYRIDIN-2-YL)BENZALDEHYDE WITH HYDRAZINE TO FORM 4-(PYRIDIN-2-YL)BENZALDEHYDE HYDRAZONE; CHEMICAL INTERMEDIATE TO AN ANTI-HIV DRUG | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| US-6147218-A | 2-phenylpyridine derivative and production method thereof | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0979820-A1 | 2-Phenylpyridine derivatives and production method thereof | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-02-16 | — | — | EP | disclosed |