Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.66 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.66 |
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17278137 | 0.89 | SLC7A5 (0.71) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Maleic Acid SCHEMBL7312418 | 0.89 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Fumaric Acid SCHEMBL7312428 | 0.89 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL1045800 | 0.88 | SLC6A4 (0.71) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL684955 | 0.87 | SLC6A4 (0.66) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL5405168 | 0.87 | SLC6A4 (0.66) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL7051306 | 0.86 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL7053112 | 0.83 | SLC6A4 (0.70) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL5398425 | 0.83 | SLC6A4 (0.66) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL7049684 | 0.83 | SLC6A4 (0.66) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831799-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS | NPS PHARMA INC (US) | 2003-05-02 | — | — | EP | claimed |
| EP-0831799-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS | NPS PHARMA INC (US) | 2003-05-02 | — | — | EP | disclosed |