Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055488 | 0.84 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DTP53 | |
| Hydrochloric Acid SCHEMBL7051870 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7053592 | 0.83 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7052620 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7056821 | 0.83 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7053642 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| Hydrochloric Acid SCHEMBL7052441 | 0.82 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7056840 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7055628 | 0.82 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7055496 | 0.79 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | claimed |
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | disclosed |
| US-5891878-A | Quinolones and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0841929-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004779-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1997-02-13 | — | — | WO | disclosed |