Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 1.00 |
| ▸ | JAK2 | O60674 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 14/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5898687 | 0.91 | IKBKB (0.83) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3615255 | 0.87 | IKBKB (0.77) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3620119 | 0.86 | IKBKB (0.76) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3606231 | 0.86 | CHEK1 (0.77) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL7055110 | 0.85 | IKBKB (0.74) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3613581 | 0.84 | IKBKB (0.72) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3616105 | 0.84 | IKBKB (0.72) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3607431 | 0.83 | IKBKB (0.71) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3613585 | 0.83 | IKBKB (0.71) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3611847 | 0.83 | IKBKB (0.71) | IKBKBJAK2MEN1EIF2AK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |