Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374672 | 0.95 | SLC6A2 (0.60) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25335598 | 0.88 | SLC6A2 (0.59) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25336072 | 0.87 | SLC6A2 (0.57) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25336074 | 0.86 | SLC6A2 (0.56) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18956784 | 0.85 | SLC6A2 (0.68) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12894408 | 0.85 | SLC6A2 (0.68) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15054178 | 0.84 | SLC6A2 (0.66) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31518364 | 0.84 | SLC6A2 (0.66) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19878954 | 0.82 | SLC6A2 (0.71) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29739455 | 0.82 | SLC6A2 (0.71) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003026666-A1 | 2-PHENYLAMINO-4- (5-PYRAZOLYLAMINO)-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, AS SRC KINASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |