Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11088738 | 0.91 | AKR1B1 (0.74) | AKR1B1TDP1L3MBTL1CES1MAPK14 | |
| SCHEMBL16091063 | 0.91 | AKR1B1 (0.63) | AKR1B1HRH1 | |
| SCHEMBL16091078 | 0.85 | AKR1B1 (0.67) | AKR1B1 | |
| SCHEMBL14710258 | 0.83 | AKR1B1 (0.61) | AKR1B1TDP1MAPK14 | |
| SCHEMBL10922819 | 0.82 | AKR1B1 (0.79) | AKR1B1HRH1 | |
| SCHEMBL1347195 | 0.81 | AKR1B1 (0.58) | AKR1B1TDP1 | |
| SCHEMBL8600926 | 0.80 | AKR1B1 (0.60) | AKR1B1TDP1L3MBTL1 | |
| Isoxepac SCHEMBL24970 | 0.80 | AKR1B1 (0.81) | AKR1B1HRH1 | |
| SCHEMBL16091057 | 0.80 | AKR1B1 (0.54) | AKR1B1 | |
| Isoxepac SCHEMBL29588437 | 0.80 | AKR1B1 (0.81) | AKR1B1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042268-B1 | 1,7-DIBROMODIBENZOSUBERONE AND PROCEDURES FOR ITS PREPARATION | BELUPO LIJEKOVI I KOZMETIKA D (HR) | 2003-05-07 | — | — | EP | disclosed |
| EP-1042268-A1 | DIBENZOSUBERONE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION | Belupo - Lijekovi I Kozmetika D.O.O. (HR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999028284-A1 | DIBENZOSUBERONE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION | BELUPO - LIJEKOVI I KOZMETIKA D.O.O. (HR) | 1999-06-10 | — | — | WO | disclosed |
| US-4172949-A | 2,4-Disubstituted-5-oxo-5H-dibenzo[a,d]cycloheptenes | SYNTEX (U.S.A.) INC. (US) | 1979-10-30 | — | — | US | disclosed |
| US-4020094-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | SYNTEX (U.S.A.) INC. (US) | 1977-04-26 | — | — | US | disclosed |