Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057653 | 1.00 | KDR (0.47) | KDREGFRERBB2METMERTK | |
| SCHEMBL7051385 | 0.90 | NPY1R (0.55) | KDREGFRERBB2METMERTK | |
| SCHEMBL7051383 | 0.90 | NPY1R (0.55) | KDREGFRERBB2METMERTK | |
| SCHEMBL7050021 | 0.88 | KCNK3 (0.44) | SMN1; SMN2MAPTHTTNPC1RAB9A | |
| SCHEMBL7050023 | 0.88 | KCNK3 (0.44) | SMN1; SMN2MAPTHTTNPC1RAB9A | |
| SCHEMBL7054646 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTHTTNPC1RAB9A | |
| SCHEMBL8397556 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTHTTNPC1RAB9A | |
| SCHEMBL7054644 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTHTTNPC1RAB9A | |
| SCHEMBL7055634 | 0.85 | NPY1R (0.39) | KDRSMN1; SMN2MAPTHTTNPC1 | |
| SCHEMBL7055539 | 0.84 | MAPT (0.53) | SMN1; SMN2MAPTNPC1RAB9AACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316617-B1 | FOR TREATING PHYSIOLOGICAL DISORDERS ASSOCIATED WITH AN EXCESS OF NEUROPEPTIDE Y, SUCH AS FEEDING DISORDERS AND CERTAIN CARDIOVASCULAR DISEASES, MEDICAL DIAGNOSIS | NEUROGEN CORPORATION | 2001-11-13 | — | — | US | claimed |
| EP-0918761-B1 | CERTAIN AMIDO- AND AMINO-SUBSTITUTED BENZYLAMINE DERIVATIVES; A NEW CLASS OF NEUROPEPTITE Y1 SPECIFIC LIGANDS | NEUROGEN CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6316617-B1 | FOR TREATING PHYSIOLOGICAL DISORDERS ASSOCIATED WITH AN EXCESS OF NEUROPEPTIDE Y, SUCH AS FEEDING DISORDERS AND CERTAIN CARDIOVASCULAR DISEASES, MEDICAL DIAGNOSIS | NEUROGEN CORPORATION | 2001-11-13 | — | — | US | disclosed |
| US-6133265-A | Certain amido- and amino- substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands | NEUROGEN CORPORATION (US) | 2000-10-17 | — | — | US | disclosed |