Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10051888 | 0.89 | IKBKB (0.73) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL5898667 | 0.87 | IKBKB (0.74) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL7052455 | 0.85 | IKBKB (0.60) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL7057743 | 0.85 | IKBKB (0.60) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL5898681 | 0.84 | JAK2 (0.61) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL7055914 | 0.84 | JAK2 (0.61) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL7056909 | 0.84 | IKBKB (0.82) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL7058327 | 0.81 | IKBKB (0.58) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL5898642 | 0.81 | IKBKB (0.58) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL5898657 | 0.80 | IKBKB (0.76) | IKBKBJAK2JAK3CHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |