Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | MRE11 | P49959 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14558383 | 0.86 | CDK5 (0.55) | CDK5CDK5R1ADORA3PDE10ANPC1 | |
| SCHEMBL14558395 | 0.84 | CDK5 (0.53) | CDK5CDK5R1ADORA3PDE10ANPC1 | |
| SCHEMBL5347132 | 0.84 | CDK5 (0.61) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL7061711 | 0.83 | CDK5 (0.52) | CDK5CDK5R1ADORA3PDE10ANPC1 | |
| SCHEMBL5338684 | 0.82 | CDK5 (0.74) | CDK5CDK5R1ADORA3PDE10ANPC1 | |
| SCHEMBL7120603 | 0.75 | CDK5 (0.43) | CDK5CDK5R1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7061875 | 0.73 | CDK5 (0.57) | CDK5CDK5R1ADORA2AADORA1CCNA2 | |
| SCHEMBL14558360 | 0.73 | CDK5 (0.57) | CDK5CDK5R1ADORA3PDE10ANPC1 | |
| SCHEMBL14558371 | 0.73 | CDK5 (0.57) | CDK5CDK5R1ADORA3PDE10ANPC1 | |
| SCHEMBL14558401 | 0.72 | CDK5 (0.57) | CDK5CDK5R1ADORA3PDE10ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |