Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 2/20 | 0.52 |
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLB1 | P16278 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805481 | 1.00 | TYMS (0.52) | TYMSALDH1A1CYP2C19F2EDNRA | |
| SCHEMBL3813102 | 1.00 | TYMS (0.52) | TYMSALDH1A1CYP2C19F2EDNRA | |
| SCHEMBL5706271 | 0.88 | TYMS (0.54) | TYMSCYP2C19F2EDNRAPRSS1 | |
| SCHEMBL6266410 | 0.88 | TYMS (0.54) | TYMSF2EDNRAPRSS1PRSS2 | |
| SCHEMBL8842854 | 0.87 | TYMS (0.53) | TYMSF2EDNRAPRSS1PRSS2 | |
| SCHEMBL13066809 | 0.87 | TYMS (0.53) | TYMSF2EDNRAPRSS1PRSS2 | |
| SCHEMBL180018 | 0.87 | TYMS (0.53) | TYMSF2EDNRAPRSS1PRSS2 | |
| SCHEMBL180019 | 0.87 | TYMS (0.53) | TYMSF2EDNRAPRSS1PRSS2 | |
| SCHEMBL13884437 | 0.87 | TYMS (0.53) | TYMSF2EDNRAPRSS1PRSS2 | |
| SCHEMBL179968 | 0.86 | TYMS (0.52) | TYMSCYP2C19F2EDNRAPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180282530-A1 | APPLICATION OF CYCLODEXTRINS (CDS) FOR REMEDIATION OF PERFLUOROALKYL SUBSTANCES (PFASS) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-10-04 | — | — | US | claimed |
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | THOMPSON LORIN A (US) | 2003-07-10 | — | — | US | claimed |
| US-6503901-B1 | Alzheimer*s disease and Down*s syndrome treatment | BRISTOL MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | claimed |
| EP-1218377-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2002-07-03 | — | — | EP | claimed |
| WO-2001027108-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-04-19 | — | — | WO | claimed |
| CN-119174932-A | Preparation method of capillary chromatographic column based on metal organic framework material and used for chiral separation | 上海大学 | 2024-12-24 | — | — | CN | disclosed |
| US-12043732-B2 | Application of cyclodextrins (CDs) for remediation of perfluoroalkyl substances (PFASs) | THE FLORIDA INTERNATIONAL UNIVERISITY BOARD OF TRUSTEES (US) | 2024-07-23 | — | — | US | disclosed |
| US-20220023332-A1 | Application of Cyclodextrins (CDs) for Remediation of Perfluoroalkyl Substances (PFASs) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2022-01-27 | — | — | US | disclosed |
| US-11149135-B2 | Application of cyclodextrins (CDS) for remediation of perfluoroalkyl substances (PFASS) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2021-10-19 | — | — | US | disclosed |
| CN-111001187-B | Preparation method of novel cyclodextrin metal organic framework material chiral capillary electrochromatography open tubular column | 武汉大学 | 2021-02-19 | — | — | CN | disclosed |
| CN-111001187-A | Preparation method of novel cyclodextrin metal organic framework material chiral capillary electrochromatography open tubular column | 武汉大学 | 2020-04-14 | — | — | CN | disclosed |
| US-20180282530-A1 | APPLICATION OF CYCLODEXTRINS (CDS) FOR REMEDIATION OF PERFLUOROALKYL SUBSTANCES (PFASS) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-10-04 | — | — | US | disclosed |
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | THOMPSON LORIN A (US) | 2003-07-10 | — | — | US | disclosed |
| US-6528642-B1 | ALKENYLATED CYCLODEXTRIN COMPOUNDS AND POLYMERS MADE TTHEREOF ; MADE BY REACTING AN ALKENYL HALIDE WITH CYCLODEXTRIN; USE AS SUPPORT FOR SEPARATION OF ENANTIOMERS, OTHER ISOMERS, AND HYDROPHOBIC ORGANIC MOLECULES, OR AS CATALYST SUPPORT | INSTITUT FRANCAIS DU PETROLE (FR) | 2003-03-04 | — | — | US | disclosed |
| US-6503901-B1 | Alzheimer*s disease and Down*s syndrome treatment | BRISTOL MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | disclosed |
| EP-1222176-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1218377-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027091-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |
| WO-2001027108-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | APP, APH1A, BACE1 | TYMS 1396/4885ALDH1A1 3364/4885CYP2C19 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.