⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607546 | 0.93 | — | — | |
| SCHEMBL11035746 | 0.72 | — | — | |
| SCHEMBL19215672 | 0.71 | — | — | |
| SCHEMBL10587843 | 0.71 | CRBN (0.43) | — | |
| SCHEMBL321022 | 0.69 | — | — | |
| SCHEMBL1320483 | 0.69 | — | — | |
| SCHEMBL9573543 | 0.69 | — | — | |
| SCHEMBL607730 | 0.67 | — | — | |
| SCHEMBL1035316 | 0.67 | TSHR (0.30) | — | |
| SCHEMBL1036695 | 0.65 | PHF8 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | THOMPSON LORIN A (US) | 2003-07-10 | — | — | US | disclosed |
| US-6503901-B1 | Alzheimer*s disease and Down*s syndrome treatment | BRISTOL MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | disclosed |