Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.71 |
| ▸ | KDR | P35968 | 1/20 | 0.71 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.69 |
| ▸ | FYN | P06241 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 2/20 | 0.69 |
| ▸ | BCR | P11274 | 2/20 | 0.69 |
| ▸ | RAF1 | P04049 | 1/20 | 0.67 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131283 | 0.93 | SRC (0.68) | SRCKDRMAP2K1FYNABL1 | |
| Hydrochloric Acid SCHEMBL7125231 | 0.93 | SRC (0.67) | SRCKDRMAP2K1FYNABL1 | |
| SCHEMBL7133745 | 0.91 | SRC (0.59) | SRCKDRMAP2K1FYNABL1 | |
| SCHEMBL7259167 | 0.91 | SRC (0.65) | SRCKDRMAP2K1FYNABL1 | |
| SCHEMBL7065304 | 0.90 | SRC (0.73) | SRCMAP2K1FYNABL1BCR | |
| SCHEMBL7131329 | 0.89 | IGF1R (0.58) | SRCKDRMAP2K1FYNABL1 | |
| SCHEMBL7128828 | 0.89 | SRC (0.56) | SRCKDRMAP2K1FYNABL1 | |
| SCHEMBL7065351 | 0.87 | SRC (0.60) | SRCMAP2K1FYNABL1BCR | |
| Hydrochloric Acid SCHEMBL7065284 | 0.85 | SRC (0.58) | SRCFYNABL1BCREGFR | |
| Hydrochloric Acid SCHEMBL7066639 | 0.85 | SRC (0.66) | SRCMAP2K1ABL1BCREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | claimed |