Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | FLT3 | P36888 | 7/20 | 0.46 |
| ▸ | KIT | P10721 | 6/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | LTK | P29376 | 2/20 | 0.42 |
| ▸ | GRK5 | P34947 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | MST1R | Q04912 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823558 | 0.88 | KDR (0.44) | KDRFLT3KITAURKBMAP4K4 | |
| SCHEMBL4789534 | 0.77 | MEN1 (0.38) | KEAP1MAP2K1CSF1RMAPTALDH1A1 | |
| SCHEMBL2445430 | 0.71 | KDR (0.58) | KDRFLT3KITAURKBMAP4K4 | |
| Hydrochloric Acid SCHEMBL5103456 | 0.70 | KDR (0.56) | KDRFLT3KITAURKBMAP4K4 | |
| SCHEMBL8574040 | 0.69 | CYP1A2 (0.35) | KEAP1CSF1RMAPTALDH1A1L3MBTL1 | |
| SCHEMBL2882058 | 0.68 | KDR (0.57) | KDRFLT3KITAURKBMAP4K4 | |
| SCHEMBL1781743 | 0.68 | KDR (0.54) | KDRFLT3KITAURKBMAP4K4 | |
| SCHEMBL8249434 | 0.68 | KDR (0.54) | KDRFLT3KITAURKBMAP4K4 | |
| SCHEMBL16646799 | 0.68 | KDR (0.57) | KDRFLT3KITAURKBMAP4K4 | |
| SCHEMBL420820 | 0.68 | KDR (0.54) | KDRFLT3KITAURKBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135023-A4 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1135023-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000027199-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000027627-A1 | ARYLOXIME LINKERS IN THE SOLID-PHASE SYNTHESIS OF 3-AMINOBENZISOXAZOLES | ELI LILLY AND COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |