Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.48 |
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7254302 | 0.87 | EGFR (0.45) | EGFRERBB2SRCABL1ABL2 | |
| SCHEMBL5461516 | 0.82 | SRC (0.52) | EGFRSRCABL1ABL2FLT1 | |
| SCHEMBL2202697 | 0.77 | SRC (0.59) | EGFRERBB2SRC | |
| SCHEMBL4029452 | 0.76 | EGFR (0.60) | EGFRERBB2SRCFLT1KCNH2 | |
| SCHEMBL7065293 | 0.75 | SRC (0.46) | EGFRERBB2SRCABL1ABL2 | |
| Hydrochloric Acid SCHEMBL7070735 | 0.74 | SRC (0.45) | EGFRERBB2SRCABL1ABL2 | |
| SCHEMBL3130466 | 0.74 | HRH3 (0.55) | EGFRFLT1KCNH2HRH3CHRM4 | |
| SCHEMBL5664245 | 0.71 | EGFR (0.45) | EGFRERBB2SRCFLT1KCNH2 | |
| SCHEMBL16667831 | 0.70 | ABL1 (0.46) | EGFRSRCABL1ABL2FLT1 | |
| SCHEMBL4027494 | 0.70 | PARP1 (0.48) | EGFRERBB2SRCKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047582-A1 | QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003048159-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |