Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.74 |
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069342 | 1.00 | PTPN1 (0.74) | PTPN1HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL7066855 | 0.93 | HPGD (0.64) | PTPN1HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL7066857 | 0.93 | HPGD (0.64) | PTPN1HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL6927265 | 0.87 | MEN1 (0.73) | PTPN1HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL6927263 | 0.87 | MEN1 (0.73) | PTPN1HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL6929711 | 0.87 | HPGD (0.72) | PTPN1HPGDKDM4EPOLBCNR1 | |
| SCHEMBL6929714 | 0.87 | HPGD (0.72) | PTPN1HPGDKDM4EPOLBCNR1 | |
| SCHEMBL8182716 | 0.84 | PTPN1 (1.00) | PTPN1HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL8182719 | 0.84 | PTPN1 (1.00) | PTPN1HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL6923861 | 0.82 | CNR1 (0.80) | PTPN1HPGDPOLBCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | claimed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | claimed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | claimed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | claimed |
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |