Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.48 |
| ▸ | WEE1 | P30291 | 1/20 | 0.48 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296487 | 0.90 | SRC (0.54) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL22589482 | 0.89 | SRC (0.59) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL14418088 | 0.89 | SRC (0.57) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL4487395 | 0.89 | SRC (0.53) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL29365909 | 0.89 | SRC (0.59) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL2977174 | 0.88 | SRC (0.54) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL4741681 | 0.88 | SRC (0.66) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL1893090 | 0.87 | SRC (0.62) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL29590073 | 0.87 | SRC (0.62) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL5470207 | 0.87 | SRC (0.53) | SRCABL1BCREGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003048159-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |