Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | FNTA | P49354 | 5/20 | 0.59 |
| ▸ | FNTB | P49356 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.53 |
| ▸ | SQLE | Q14534 | 4/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992758 | 0.92 | KMT2A (0.70) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL27843331 | 0.92 | KMT2A (0.70) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL12818876 | 0.92 | KMT2A (0.70) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL4663422 | 0.92 | KMT2A (0.70) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL24434263 | 0.86 | KMT2A (0.67) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL15158145 | 0.86 | KMT2A (0.67) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL8657303 | 0.84 | KMT2A (0.64) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL5082786 | 0.84 | KMT2A (0.64) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| Squalene SCHEMBL6425147 | 0.84 | KMT2A (0.77) | KMT2AFNTAFNTBKDM4EMAPT | |
| Squalene SCHEMBL27987016 | 0.84 | KMT2A (0.77) | KMT2AFNTAFNTBKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158995-B1 | BIOLOGICALLY ACTIVE COMPOUNDS OF GANODERMA PFEIFFERI DMS 13239 | GANOMYCIN GES FUER BIOMEDIZINI (DE) | 2003-06-18 | — | — | EP | disclosed |
| EP-1158995-A1 | BIOLOGICALLY ACTIVE COMPOUNDS OF GANODERMA PFEIFFERI DMS 13239 | Ganomycin Gesellschaft für Biomedizinische Forschung mbH (DE) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000053207-A1 | BIOLOGICALLY ACTIVE COMPOUNDS OF $I(GANODERMA PFEIFFERI) DMS 13239 | GANOMYCIN GESELLSCHAFT FÜR BIOMEDIZINISCHE FORSCHUNG MBH ; (DE) | 2000-09-14 | — | — | WO | disclosed |