Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068965 | 0.76 | EPHX2 (0.45) | KDM1AMAOBEPHX2KMT2AL3MBTL1 | |
| SCHEMBL6068960 | 0.76 | EPHX2 (0.45) | KDM1AMAOBEPHX2KMT2AL3MBTL1 | |
| SCHEMBL7986840 | 0.71 | BRD4 (0.48) | KDM1AMAOBEPHX2KMT2AL3MBTL1 | |
| SCHEMBL29264385 | 0.71 | BRD4 (0.48) | KDM1AMAOBEPHX2KMT2AL3MBTL1 | |
| SCHEMBL8430929 | 0.71 | BRD4 (0.53) | EPHX2GAANFKB1NFKB2RELA | |
| SCHEMBL5757370 | 0.71 | KMT2A (0.52) | KMT2AMEN1TDP1 | |
| SCHEMBL6069059 | 0.68 | BCHE (0.35) | KDM1AKMT2AMEN1 | |
| SCHEMBL4949895 | 0.68 | GAA (0.55) | KDM1AMAOBEPHX2KMT2AL3MBTL1 | |
| SCHEMBL3375618 | 0.68 | PDE4A (0.52) | EPHX2KMT2AMEN1DRD2 | |
| SCHEMBL3375614 | 0.68 | PDE4A (0.52) | EPHX2KMT2AMEN1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370547-A1 | BENZOAXATHIEPIN DERIVATIVES AND THEIR USE AS MEDICINES | PIERRE FABRE MEDICAMENT (FR) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002081464-A1 | BENZOAXATHIEPIN DERIVATIVES AND THEIR USE AS MEDICINES | PIERRE FABRE MEDICAMENT (FR) | 2002-10-17 | — | — | WO | disclosed |