Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.65 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.60 |
| ▸ | PRKACA | P17612 | 4/20 | 0.60 |
| ▸ | AKT2 | P31751 | 3/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.60 |
| ▸ | PAK4 | O96013 | 3/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.60 |
| ▸ | PRKCG | P05129 | 3/20 | 0.60 |
| ▸ | PIM1 | P11309 | 3/20 | 0.60 |
| ▸ | PHKG2 | P15735 | 3/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.60 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.60 |
| ▸ | GSK3A | P49840 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849681 | 1.00 | AKT1 (0.65) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6853332 | 0.93 | AKT1 (0.60) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6855551 | 0.91 | AKT1 (0.68) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6857943 | 0.91 | AKT1 (0.77) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6857773 | 0.90 | AKT1 (0.77) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6855237 | 0.90 | AKT1 (0.65) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6854820 | 0.90 | AKT1 (0.77) | AKT1AKT3PRKACAAKT2PIM1 | |
| SCHEMBL6855175 | 0.90 | AKT1 (0.65) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6853324 | 0.90 | AKT1 (0.64) | AKT1AKT3PRKACAAKT2DAPK3 | |
| SCHEMBL6854493 | 0.90 | AKT1 (0.65) | AKT1AKT3PRKACAAKT2DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | claimed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | claimed |