Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474866 | 0.94 | KDM4E (0.55) | KDM4ELMNAHDAC1HDAC6RAB9A | |
| SCHEMBL6937964 | 0.91 | PTGDR2 (0.55) | KDM4ELMNAHDAC1HDAC6PTGDR2 | |
| SCHEMBL6475292 | 0.91 | HDAC1 (0.56) | KDM4EHDAC1HDAC6PTGDR2CHRM2 | |
| SCHEMBL14067841 | 0.88 | HDAC1 (0.61) | KDM4ELMNAHDAC1HDAC6RAB9A | |
| SCHEMBL6482626 | 0.82 | PTGDR2 (0.64) | KDM4EHDAC1HDAC6PTGDR2CHRM2 | |
| SCHEMBL14067957 | 0.82 | HDAC1 (0.60) | KDM4EHDAC1HDAC6PTGDR2L3MBTL1 | |
| SCHEMBL7184255 | 0.82 | HDAC1 (0.49) | KDM4ELMNAHDAC1HDAC6PTGDR2 | |
| SCHEMBL7073336 | 0.82 | HDAC1 (0.49) | KDM4EHDAC1HDAC6RAB9APTGDR2 | |
| SCHEMBL6480581 | 0.82 | HDAC1 (0.54) | KDM4EHDAC1HDAC6PTGDR2CHRM2 | |
| SCHEMBL6482888 | 0.81 | HDAC1 (0.55) | KDM4EHDAC1HDAC6PTGDR2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319005-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024700-A2 | SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |