Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ARHGDIA | P52565 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072578 | 0.88 | GRIN2B (0.67) | GRIN2BGRIN1GRIN2ADRD4IDO1 | |
| SCHEMBL7012695 | 0.82 | GRIN2B (0.77) | GRIN2BGRIN1GRIN2ADRD4GRIN2C | |
| SCHEMBL6945290 | 0.82 | GRIN1 (0.43) | GRIN2BGRIN1KCNH2OPRM1OPRD1 | |
| SCHEMBL7074975 | 0.79 | GRIN1 (0.56) | GRIN2BGRIN1DRD4IDO1 | |
| SCHEMBL7074921 | 0.79 | GRIN2B (0.56) | GRIN2BGRIN1GRIN2ADRD4IDO1 | |
| SCHEMBL7075826 | 0.79 | GRIN1 (0.56) | GRIN2BGRIN1DRD4IDO1 | |
| SCHEMBL7072074 | 0.77 | GRIN1 (0.53) | GRIN2BGRIN1KCNH2OPRM1OPRD1 | |
| SCHEMBL7076802 | 0.77 | GRIN2B (0.56) | GRIN2BGRIN1KCNH2OPRM1OPRD1 | |
| SCHEMBL7073348 | 0.77 | GRIN1 (0.53) | GRIN2BGRIN1KCNH2OPRM1OPRD1 | |
| SCHEMBL7072398 | 0.77 | GRIN1 (0.53) | GRIN2BGRIN1KCNH2DRD4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244450-A4 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2003-03-19 | — | — | EP | claimed |
| EP-1244450-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-10-02 | — | — | EP | claimed |
| WO-2001032179-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | claimed |
| EP-1244450-A4 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1244450-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6432976-B1 | ANALGESICS; SIDE EFFECT REDUCTION | MERCK & CO., INC. | 2002-08-13 | — | — | US | disclosed |
| WO-2001032179-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |