Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.74 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.74 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.56 |
| ▸ | LMNA | P02545 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695450 | 0.88 | STIM1 (0.59) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL705705 | 0.85 | STIM1 (1.00) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL29420774 | 0.85 | STIM1 (1.00) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL700946 | 0.85 | STIM1 (0.55) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL757594 | 0.85 | STIM1 (0.98) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL757593 | 0.85 | STIM1 (0.98) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL759966 | 0.81 | STIM1 (0.71) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL758607 | 0.80 | STIM1 (0.65) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL756398 | 0.80 | STIM1 (0.65) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL696026 | 0.78 | STIM1 (0.79) | STIM1ORAI1ORAI3SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421835-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |